ausgewählte Publikationen

  • Prasser F, Kohlmayer F, Spengler H, Kuhn KA. A scalable and pragmatic method for the safe sharing of high-quality health data. IEEE Journal of Biomedical and Health Informatics. 2017. doi: 10.1109/JBHI.2017.2676880 [epub ahead of print]
  • Brandizi M, Melnichuk O, Bild R, Kohlmayer F, Rodriguez-Castro B, Spengler H, Kuhn KA, Kuchinke W, Ohmann C, Mustonen T, Linden M, Nyrönen T, Lappalainen I, Brazma A, Sarkans U. Orchestrating differential data access for translational research: a pilot implementation. BMC Med Inform Decis Mak. 2017 Mar 23;17(1):30. doi: 10.1186/s12911-017-0424-6
  • Prasser F, Bild R, Kuhn KA. A generic method for assessing the quality of de-identified health data. Proc MIE 2016 at HEC 2016. August 2016. IOS Press. doi: 10.3233/978-1-61499-678-1-312
    F Prasser hat für diese Arbeit den Peter L Reichertz Preis erhalten.
  • Prasser F, Kohlmayer F, Kuhn KA. The Importance of Context: Risk-based De-identification of Biomedical Data. Methods Inf Med. 2016 Aug 5;55(4):347-55. doi: 10.3414/ME16-01-0012
  • Prasser F, Kohlmayer F, Kuhn KA.  Efficient and effective pruning strategies for health data de-identification. BMC Med Inform Decis Mak. 2016 Apr 30;16:49. doi: 10.1186/s12911-016-0287-2
  • Altmann J, Büchner B, Nadaj-Pakleza A, Schäfer J, Jackson S, Lehmann D, Deschauer M, Kopajtich R, Lautenschläger R, Kuhn KA, Karle K, Schöls L, Schulz JB, Weis J, Prokisch H, Kornblum C, Claeys KG, Klopstock T. Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry. J Neurol. 2016 May;263(5):961-72. doi: 10.1007/s00415-016-8086-3. Epub 2016 Mar 19.
  • Kuhn KA, Bild R, Anton G, Schuffenhauer S, Wichmann HE. Connecting biobanks of large European cohorts (EU Project BBMRI-LPC). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Mar;59(3):385-9. doi: 10.1007/s00103-015-2300-9
  • Lautenschläger R, Kohlmayer F, Prasser F, Kuhn KA. A generic solution for web-based management of pseudonymized data. BMC Med Inform Decis Mak. 2015 Nov 30;15(1):100. doi: 10.1186/s12911-015-0222-y
  • Kohlmayer F, Prasser F, Kuhn KA.  The cost of quality: Implementing generalization and suppression for anonymizing biomedical data with minimal information loss. J Biomed Inform. 2015 Dec;58:37-48. doi: 10.1016/j.jbi.2015.09.007. Epub 2015 Sep 15
  • Prasser F, Kohlmayer F, Lautenschläger R, Kuhn KA. ARX--A Comprehensive Tool for Anonymizing Biomedical Data. AMIA Annu Symp Proc. 2014 Nov 14;2014:984-93. eCollection 2014.
  • Kohlmayer F, Prasser F, Eckert C, Kuhn KA.  A flexible approach to distributed data anonymization. J Biomed Inform. 2014 Aug;50:62-76. doi: 10.1016/j.jbi.2013.12.002. Epub 2013 Dec 12.
  • Oßwald A, Plomer E, Dimopoulou C, Milian M, Blaser R, Ritzel K, Mickisch A, Knerr F, Stanojevic M, Hallfeldt K, Schopohl J, Kuhn KA, Stalla G, Beuschlein F, Reincke M. Favorable long-term outcomes of bilateral adrenalectomy in Cushing's disease. Eur J Endocrinol. 2014 Aug;171(2):209-15. doi: 10.1530/EJE-14-0214.
  • Riediger C, Mueller MW, Geismann F, Lehmann A, Schuster T, Michalski CW, Kuhn KA, Friess H.Comparative analysis of different transection techniques in minor and major hepatic resections: a prospective cohort study. Int J Surg. 2013;11(9):826-33. doi: 10.1016/j.ijsu.2013.08.010. Epub 2013 Aug 28.
  • Lauss G, Schröder C, Dabrock P, Eder J, Hamacher K, Kuhn KA, Gottweis H. Towards Biobank Privacy Regimes in Responsible Innovation Societies: ESBB Conference in Granada 2012. Biopreservation and Biobanking October 2013, 11(5): 319-323. doi: 10.1089/bio.2013.0036
  • Kalman B, Lautenschlaeger R, Kohlmayer F, Büchner B, Kmiec T, Klopstock T, Kuhn KA. An international registry for neurodegeneration with brain iron accumulation. Orphanet J Rare Dis. 2012 Sep 17;7:66. doi: 10.1186/1750-1172-7-66
  • Prasser F, Kemper A, Kuhn KA. Efficient distributed query processing for autonomous RDF databases. Proc 15th IntConf on Extending Database Technology, EDBT 2012. ACM New York, NY, USA, 372-383. doi: 10.1145/2247596.2247640
  • Kohlmayer F, Prasser F, Eckert C, Kemper A, Kuhn KA. Flash: efficient, stable and optimal k-anonymity.Proc 4th IEEE IntConf on Information Privacy, Security, Risk and Trust, PASSAT 2012
  • Wichmann HE, Kuhn KA, Waldenberger M, Schmelcher D, Schuffenhauer S, Meitinger T, Wurst SH, Lamla G, Fortier I, Burton PR, Peltonen L, Perola M, Metspalu A, Riegman P, Landegren U, Taussig MJ, Litton JE, Fransson MN, Eder J, Cambon-Thomsen A, Bovenberg J, Dagher G, van Ommen GJ, Griffith M, Yuille M, Zatloukal K.: Comprehensive catalog of European biobanks. Nat Biotechnol. 2011 Sep 8;29(9):795-7. doi: 10.1038/nbt.1958
    HE Wichmann and KA Kuhn contributed equally to this work.
  • Feulner TM, Laws SM, Friedrich P, Wagenpfeil S, Wurst SH, Riehle C, Kuhn KA, Krawczak M, Schreiber S, Nikolaus S, Förstl H, Kurz A, Riemenschneider M.: Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry. 2009 Jan 6. doi: 10.1038/mp.2008.141
  • Kuhn KA, Knoll A, Mewes HW, Schwaiger M, Bode A, Broy M, Daniel H, Feussner H, Gradinger R, Hauner H, Höfler H, Holzmann B, Horsch A, Kemper A, Krcmar H, Kochs EF, Lange R, Leidl R, Mansmann U, Mayr EW, Meitinger T, Molls M, Navab N, Nüsslin F, Peschel C, Reiser M, Ring J, Rummeny EJ, Schlichter J, Schmid R, Wichmann HE, Ziegler S.: Informatics and medicine--from molecules to populations. Methods Inf Med 2008; 47(4):283-95. doi: 10.3414/ME9117
  • Kuhn KA, Guise DA, Lapao L, Wurst SHR: Expanding the Scope of Health Information Systems From Hospitals to Regional Networks, to National Infrastructures and Beyond. Meth Inf Med 2007; 46(4):500-502. doi: 10.1160/ME9058
  • Dibra A, Kastrati A, Mehilli J, Pache J, Schühlen H, von Beckerath N, Ulm K, Wessely R, Dirschinger J, Schömig A (2005). Paclitaxel-Eluting or Sirolimus-Eluting Stents to Prevent Restenosis in Diabetic Patients, NEJM - The New England Journal of Medicine 353;7: 663-670. doi: 10.1056/NEJMoa044372
  • Kastrati A, Dibra A, Eberle S, Mehilli J, de Lezo JS, Ulm K, Schömig A (2005). Sirolimus-Eluting Stents vs Patlitaxel-Eluting Stents in Patients With Coronary Artery Disease - Meta-Analysis of Randomized Trials, JAMA 294 (7) 819-825. doi: 10.1001/jama.294.7.819
  • Becker-Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hummelsberger J, Walther HU, Melchart D, Willich SN (2005). Acupuncture in Patients with Osteoarthritis of the Knee - A Randomized Trial (ART Osteoarthritis), The Lancet 366, 136-143. doi: 10.1016/S0140-6736(05)66871-7
  • Lenz R, Buessecker F, Herlofsen H, Hinrichs F, Zeiler T, Kuhn KA. Demand-driven Evolution of IT-systems in Healthcare - A Case Study for Improving Interdisciplinary Processes. Method Inform Med 2005; 44: 4-10.
  • Linde K, Streng A, Jürgens S, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, Pfaffenrath V, Hammes M, Weidenhammer W, Willich SN, Melchart D (2005). Acupuncture in Patients with Migraine - A Randomized Trial (ART Migraine), JAMA - Journal of the American Medical Association 292, 293 (17), 2118-2125. doi: 10.1001/jama.293.17.2118
  • Wagenpfeil S, Treiber U, Lehmer A (2005). Statistical Analysis of Combined Dose Effects for Experiments with two Agents. Artificial Intelligence in Medicine. 2006 May. 37(1):65-71. doi: 10.1016/j.artmed.2005.01.011
  • Hamann J, Langer B, Leucht S, Busch R, Kissling W. Medical decision making in antipsychotic drug choice for schizophrenia. Am J Psychiatry. 2004 Jul;161(7):1301-4. doi: 10.1176/appi.ajp.161.7.1301
  • Lenz R, Kuhn KA. Towards a flexible, process-oriented IT architecture for an integrated healthcare network. Proceedings of the 2004 ACM Symposium on Applied Computing (SAC); ACM, 2004: 264-271. doi: 10.1145/967900.967958
  • Wendtner CM, Ritgen M, Schweighofer CD, Fingerle-Rowson G, Campe H, Jager G, Eichhorst B, Busch R, Diem H, Engert A, Stilgenbauer S, Dohner H, Kneba M, Emmerich B, Hallek M; German CLL Study Group (GCLLSG). Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission--experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia. 2004 Jun;18(6):1093-101. doi: 10.1038/sj.leu.2403354
  • Gerdesmeyer L, Wagenpfeil S, Haake M, Maier M, Loew M, Wörtler K, Lampe R, Sail R, Handle G, Gassel, S., Rompe, J., (2003). Extracorporeal Shock Wave Therapy for the Treatment of Chronic Calcifying Tendinitis of the Rotator Cuff - A Randomized Controlled Trial. JAMA 290(19), 2573-2580. doi: 10.1001/jama.290.19.2573
  • Kuhn KA, Lenz R, Elstner T, Siegele H, Moll R. Experiences with a generator tool for building clinical application modules. Method Inform Med 2003; 42: 37-44.
  • Lodick F, von Schilling C, Bernhard H, Hennig M, Bredenkamp R, Peschel C (2003). Phase II trial of irinotecan plus docetaxel in cisplatin-pretreated relapsed or refractory oesophagal cancer. British Journal of Cancer; 89:630-633. doi: 10.1038/sj.bjc.6601168
  • Huber W, Ilgmann K, Page M, Hennig M, Schweigart U, Jeschke B, Lutilsky L, Weiss W, Salmhofer H, Classen M (2002). Effect of Theophylline on Contrast Material-induced Nephropathy in Patients with Chronic Renal Insufficiency: Controlled, Randomized Double-blinded Stud. Radiology, 223:772-779. doi: 10.1148/radiol.2233010609
  • Lenz R, Elstner T, Siegele H, Kuhn KA. A practical approach to process support in health information systems. JAMIA 2002;9(6): 571-585. doi: 10.1197/jamia.M1016
  • Zanchetti A., Bond MG, Hennig M, Neiss A, Mancia G, Dal Palù C, Hansson L, Magnani B, Rahn KH, Reid JL, Rodicio J, Safar M, EckesL, Rizzini P - on behalf of the ELSA investigators (2002) Calcium Antagonist Lacipidine Slows Down Progression of Asymptomatic Carotid Atherosclerosis - Principal Results of the European Lacipidine Study on Atherosclerosis (ELSA), a Randomized, Double-Blind, Long-Term Trial. Circulation; 106:2422-2427.  doi: 10.1161/01.cir.0000039288.86470.dd
  • Kuhn KA, Giuse DA. From Hospital Information Systems to Health Information Systems - Problems, Challenges, Perspectives. Method Inform Med 2001; 40 (4): 275-287.
  • Klopstock T, Querner V, Schmidt F, Gekeler F, Walter M, Hartard M, Hennig M, Gasser T, Pongratz D, Straube A, Dieterich M, Müller-Felber W (2000). A placebo-controlled crossover trial of creatine in mitochondrial diseases. Neurology 55: 1748-1751